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July 07, 2025
Cost-Effective Method for Carboxylic Acid Activation Using Organic Photocatalysts
Researchers from WPI-ICReDD and the University of Shizuoka have developed a simple, low-cost method to activate carboxylic acids using xanthone, an inexpensive ketone photocatalyst. The method relies on hydrogen atom transfer (HAT) to selectively generate carboxy radicals, enabling the formation of C–C, C–S, and C–Cl bonds.
Using the AFIR computational technique, the team identified xanthone’s unique ability to selectively cleave O–H bonds over C–H bonds, confirmed experimentally with >10:1 selectivity. The reaction shows broad substrate scope and minimal waste, offering a sustainable approach for pharmaceuticals and materials development.